Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 11/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.31 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.30 |
| ▸ | PDE5A | O76074 | 2/20 | 0.30 |
| ▸ | BRD4 | O60885 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10762088 | 0.85 | PDE3A (0.42) | PDE3APDE3BPBRM1PTGS1PTGS2 | |
| SCHEMBL10764837 | 0.84 | PDE3A (0.46) | PDE3APDE3BPBRM1PTGS1PTGS2 | |
| SCHEMBL10765377 | 0.81 | PDE3B (0.32) | PDE3APDE3BPBRM1GPR119SLFN12 | |
| SCHEMBL10761085 | 0.81 | PDE3B (0.54) | PDE3APDE3BPBRM1GPR119SLFN12 | |
| SCHEMBL10764081 | 0.81 | PDE3B (0.38) | PDE3APDE3BPBRM1MAPTCREBBP | |
| SCHEMBL10762928 | 0.79 | PDE3B (0.45) | PDE3APDE3BPBRM1PTGS1PTGS2 | |
| SCHEMBL10764359 | 0.78 | PDE3A (0.45) | PDE3APDE3BGPR119LMNAPDE4B | |
| SCHEMBL10766026 | 0.78 | PDE3A (0.45) | PDE3APDE3BGPR119LMNAMAPT | |
| SCHEMBL10765262 | 0.78 | PTGS2 (0.52) | PDE3APDE3BPTGS1PTGS2LMNA | |
| SCHEMBL10763296 | 0.76 | PDE3A (0.43) | PDE3APDE3BPBRM1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |