Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.32 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10764370 | 0.86 | PDE3B (0.34) | KDM4EALDH1A1PDE3BPDE3APBRM1 | |
| SCHEMBL10762863 | 0.85 | BRD4 (0.41) | PDE3BPDE3APBRM1BRD4CREBBP | |
| SCHEMBL10764416 | 0.81 | PDE3A (0.40) | PDE3BPDE3APBRM1 | |
| SCHEMBL10765623 | 0.80 | PDE3A (0.43) | KDM4EALDH1A1PDE3BPDE3APBRM1 | |
| SCHEMBL10763597 | 0.80 | PDE3B (0.33) | PDE3BPDE3APBRM1BRD4CREBBP | |
| SCHEMBL10769112 | 0.80 | PDE3B (0.39) | KDM4EALDH1A1PDE3BPDE3APBRM1 | |
| SCHEMBL10764068 | 0.78 | PDE3B (0.33) | ALDH1A1PDE3BPDE3APBRM1BRD4 | |
| SCHEMBL10764444 | 0.78 | HSD17B10 (0.40) | ALDH1A1PDE3BPDE3AGPR119 | |
| SCHEMBL10765377 | 0.78 | PDE3B (0.32) | ALDH1A1PDE3BPDE3APBRM1BRD4 | |
| SCHEMBL10761913 | 0.76 | BRD4 (0.35) | KDM4EPDE3BPDE3APBRM1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |