Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 8/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.43 |
| ▸ | BRD4 | O60885 | 4/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.31 |
| ▸ | PDE5A | O76074 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10762866 | 0.85 | PDE3B (0.45) | PDE3APDE3BBRD4CREBBPPBRM1 | |
| SCHEMBL10760629 | 0.84 | CREBBP (0.54) | PDE3APDE3BBRD4CREBBPPBRM1 | |
| SCHEMBL10763554 | 0.80 | KDM4E (0.33) | PDE3APDE3BBRD4CREBBPALDH1A1 | |
| SCHEMBL10769112 | 0.80 | PDE3B (0.39) | PDE3APDE3BBRD4CREBBPALDH1A1 | |
| SCHEMBL10764072 | 0.80 | PDE3B (0.57) | PDE3APDE3BALDH1A1KDM4EPBRM1 | |
| SCHEMBL10766791 | 0.79 | PDE3B (0.46) | PDE3APDE3BBRD4CREBBPPBRM1 | |
| SCHEMBL10765683 | 0.78 | PDE3A (0.45) | PDE3APDE3BALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL10764735 | 0.78 | PDE3A (0.45) | PDE3APDE3BKDM4ELMNAMAPT | |
| SCHEMBL10767198 | 0.77 | PTGS2 (0.53) | PDE3APDE3BBRD4CREBBPALDH1A1 | |
| SCHEMBL10763296 | 0.77 | PDE3A (0.43) | PDE3APDE3BBRD4CREBBPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |