Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10763214 | 0.91 | PDE3B (0.43) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10760629 | 0.82 | CREBBP (0.54) | PDE3BPDE3AGPR119PDE4BBRD4 | |
| SCHEMBL10763860 | 0.81 | PDE3B (0.44) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10761339 | 0.81 | PDE3A (0.42) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10762558 | 0.80 | PDE3A (0.44) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10763333 | 0.80 | CREBBP (0.43) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10763829 | 0.80 | PDE3B (0.39) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10762031 | 0.80 | PDE3B (0.42) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10763163 | 0.79 | PDE3B (0.43) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL10759882 | 0.79 | RAB9A (0.60) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |