Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10766602 | 0.94 | PSEN1 (0.54) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10765096 | 0.86 | REN (0.57) | REN | |
| SCHEMBL10766672 | 0.85 | REN (0.45) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10766670 | 0.83 | REN (0.40) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10659915 | 0.82 | PSEN1 (0.59) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10661503 | 0.81 | PSEN1 (0.57) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10525394 | 0.81 | REN (0.57) | REN | |
| SCHEMBL10421165 | 0.80 | REN (0.56) | REN | |
| SCHEMBL10763972 | 0.80 | REN (0.56) | REN | |
| SCHEMBL10766725 | 0.80 | REN (0.39) | RENPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223437-A2 | Aminocarbonyl renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-05-27 | — | — | EP | disclosed |