Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.31 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10761795 | 0.88 | PDE3B (0.43) | PDE3BPDE3ABRD4CREBBPKDM4E | |
| SCHEMBL10760898 | 0.85 | PDE3B (0.37) | PDE3BPDE3ABRD4CREBBPPBRM1 | |
| SCHEMBL10765487 | 0.85 | PDE3B (0.41) | PDE3BPDE3ABRD4CREBBPALDH1A1 | |
| SCHEMBL10768474 | 0.81 | PDE3A (0.39) | PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL10769779 | 0.81 | PDE3A (0.37) | PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL10765577 | 0.81 | PDE3B (0.47) | PDE3BPDE3ABRD4CREBBPPBRM1 | |
| SCHEMBL10765539 | 0.81 | PDE3B (0.35) | PDE3BPDE3ABRD4CREBBPPBRM1 | |
| SCHEMBL10764423 | 0.80 | PDE3B (0.40) | PDE3BPDE3ABRD4CREBBPKDM4E | |
| SCHEMBL10763644 | 0.80 | PDE3B (0.37) | PDE3BPDE3ABRD4CREBBPKDM4E | |
| SCHEMBL10769532 | 0.80 | PDE3B (0.37) | PDE3BPDE3ABRD4CREBBPPBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |