Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 14/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10769779 | 0.93 | PDE3A (0.37) | PDE3APDE4BPDE3BPDE4APDE4C | |
| SCHEMBL10771165 | 0.86 | PDE3A (0.40) | PDE3APDE4BPDE3BPDE4APDE4C | |
| SCHEMBL10769626 | 0.86 | PDE3A (0.44) | PDE3APDE4BPDE3BPDE4APDE4C | |
| SCHEMBL10761795 | 0.83 | PDE3B (0.43) | PDE3APDE3BKDM4EALDH1A1 | |
| SCHEMBL10761165 | 0.83 | PDE3A (0.47) | PDE3APDE4BPDE3BPDE4APDE4C | |
| SCHEMBL10764805 | 0.82 | PDE3A (0.39) | PDE3APDE4BPDE3BPDE4APDE4C | |
| SCHEMBL10766237 | 0.81 | PDE3B (0.39) | PDE3APDE3BKDM4EALDH1A1 | |
| SCHEMBL10764957 | 0.80 | PDE3A (0.39) | PDE3APDE4BPDE3BPDE4APDE4C | |
| SCHEMBL10762825 | 0.80 | PDE3A (0.42) | PDE3APDE4BPDE3BPDE4APDE4C | |
| SCHEMBL10764423 | 0.79 | PDE3B (0.40) | PDE3APDE3BSMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |