Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.60 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GALR3 | O60755 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10763316 | 0.85 | PDE3B (0.50) | PDE3BPDE3APBRM1GALR3ALDH1A1 | |
| SCHEMBL10763910 | 0.83 | PDE3B (0.54) | PDE3BPDE3APBRM1LMNARAB9A | |
| SCHEMBL10761085 | 0.83 | PDE3B (0.54) | PDE3BPDE3APBRM1LMNARAB9A | |
| SCHEMBL10761737 | 0.82 | PDE3B (0.67) | PDE3BPDE3APBRM1LMNARAB9A | |
| SCHEMBL10764989 | 0.82 | PDE3B (0.44) | PDE3BPDE3ALMNAGALR3ALDH1A1 | |
| SCHEMBL10759796 | 0.81 | PDE3B (0.69) | PDE3BPDE3APBRM1LMNARAB9A | |
| SCHEMBL7285568 | 0.81 | PDE3B (0.65) | PDE3BPDE3APBRM1LMNARAB9A | |
| SCHEMBL10761194 | 0.81 | PDE3B (0.65) | PDE3BPDE3APBRM1LMNARAB9A | |
| SCHEMBL10761216 | 0.81 | PDE3B (0.65) | PDE3BPDE3APBRM1LMNARAB9A | |
| SCHEMBL10765163 | 0.81 | PDE3B (0.65) | PDE3BPDE3APBRM1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | claimed |
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |