Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 13/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10761102 | 0.86 | PDE3A (0.43) | PDE3BPDE3AGPR119MAPTPDE4A | |
| SCHEMBL10766295 | 0.84 | PDE3A (0.46) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL10766313 | 0.82 | PDE3B (0.60) | PDE3BPDE3AALDH1A1LMNAMAPT | |
| SCHEMBL10759920 | 0.82 | PDE3B (0.44) | PDE3BPDE3AGPR119F10PDE4A | |
| SCHEMBL10763316 | 0.81 | PDE3B (0.50) | PDE3BPDE3AALDH1A1GALR3GAA | |
| SCHEMBL10760896 | 0.81 | PDE3B (0.45) | PDE3BPDE3AGPR119F10PDE4A | |
| SCHEMBL10764837 | 0.78 | PDE3A (0.46) | PDE3BPDE3AGPR119ALDH1A1SLFN12 | |
| SCHEMBL10762031 | 0.77 | PDE3B (0.42) | PDE3BPDE3AGPR119ALDH1A1SLFN12 | |
| SCHEMBL10766207 | 0.74 | PDE3B (0.54) | PDE3BPDE3AGPR119ALDH1A1SLFN12 | |
| SCHEMBL10764887 | 0.73 | PDE3A (0.45) | PDE3BPDE3AGPR119ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | claimed |
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |