Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10768749 | 0.90 | MEN1 (0.55) | MEN1POLBRECQLKMT2ASMN1; SMN2 | |
| SCHEMBL10771496 | 0.88 | FYN (0.65) | SMN1; SMN2KDM4EFYN | |
| SCHEMBL3476495 | 0.87 | MEN1 (0.71) | MEN1POLBRECQLKMT2ASMN1; SMN2 | |
| SCHEMBL4314117 | 0.83 | MEN1 (0.56) | MEN1POLBRECQLKMT2ASMN1; SMN2 | |
| SCHEMBL10769715 | 0.80 | FYN (0.61) | FYN | |
| SCHEMBL23535616 | 0.79 | FYN (0.62) | NPC1RAB9AFYN | |
| SCHEMBL10390960 | 0.79 | BRD4 (0.58) | MEN1POLBRECQLKMT2ASMN1; SMN2 | |
| SCHEMBL10389605 | 0.78 | MEN1 (0.69) | MEN1POLBRECQLKMT2ASMN1; SMN2 | |
| SCHEMBL10389951 | 0.78 | BRD4 (0.49) | MEN1POLBRECQLKMT2ASMN1; SMN2 | |
| SCHEMBL10389914 | 0.78 | SMN1; SMN2 (0.71) | POLBRECQLKMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223974-A1 | N-Substituted-N-[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)-phenyl]alkanamides, carbamates and ureas | AMERICAN CYANAMID COMPANY (US) | 1987-06-03 | — | — | EP | disclosed |