SCHEMBL10778141

SCHEMBL10778141

O=C1CC(Cl)C(Cl)CC(=O)O1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.35
KDM4E B2RXH2 1/20 0.31
GMNN O75496 1/20 0.31
PPM1B O75688 1/20 0.31
LMNA P02545 1/20 0.31
PPP1CC P36873 1/20 0.31
TFPI2 P48307 1/20 0.31
RAB9A P51151 1/20 0.31
PPP5C P53041 1/20 0.31
PPP1CA P62136 1/20 0.31
PMP22 Q01453 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
TP53 P04637 1/20 0.31
CYP2D6 P10635 1/20 0.31
NFKB1 P19838 1/20 0.31
THPO P40225 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6519713 0.81
SCHEMBL8625739 0.78
SCHEMBL11955386 0.73 TSHR (0.47) TSHRSMN1; SMN2KDM4EGMNNPPM1B
SCHEMBL5377901 0.71
SCHEMBL19395602 0.71 TSHR (0.38) TSHRSMN1; SMN2
SCHEMBL7626529 0.71 SMN1; SMN2 (0.32) TSHRSMN1; SMN2
SCHEMBL10780946 0.71 TSHR (0.32) TSHR
SCHEMBL1995961 0.71
SCHEMBL24623985 0.69
SCHEMBL22173859 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0120411-B1 SCORCH-INHIBITED ELASTOMERIC COMPOSITION NIPPON ZEON CO., LTD. (JP) 1987-02-04 EP disclosed
US-4569958-A BLEND OF HALOGEN CONTAINING ELASTOMER, DI-OR TRI-THIOL-S-TRIAZINE,AND POLYCARBOXYLIC ACID NIPPON ZEON CO LTD (JP) 1986-02-11 US disclosed
EP-0120411-A1 Scorch-inhibited elastomeric composition NIPPON ZEON CO., LTD. (JP) 1984-10-03 EP disclosed