SCHEMBL10778264

SCHEMBL10778264

Cc1ccc(S(=O)(=O)Nc2cc(Br)c(N)c3c2C(=O)c2c(NS(=O)(=O)c4ccc(C)cc4)cc(Br)c(N)c2C3=O)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 1/20 0.57
METAP2 P50579 1/20 0.48
APP P05067 1/20 0.48
CA1 P00915 2/20 0.48
CA2 P00918 2/20 0.48
CA4 P22748 2/20 0.48
CA7 P43166 2/20 0.48
CA9 Q16790 2/20 0.48
ALDH1A1 P00352 2/20 0.48
MAPT P10636 2/20 0.48
USP2 O75604 1/20 0.48
LMNA P02545 1/20 0.48
POLB P06746 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
NOD2 Q9HC29 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
KEAP1 Q14145 1/20 0.48
NFE2L2 Q16236 1/20 0.48
GAA P10253 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10487975 1.00 CDK2 (0.57) CDK2METAP2APPCA1CA2
SCHEMBL10900097 0.91 CDK2 (0.56) CDK2METAP2APPCA1CA2
SCHEMBL11078073 0.91 CDK2 (0.71) CDK2CA1CA2CA4CA7
SCHEMBL10488023 0.89 CDK2 (0.59) CDK2CA1CA2CA4CA7
SCHEMBL10488101 0.89 CDK2 (0.59) CDK2CA1CA2CA4CA7
SCHEMBL10488020 0.88 CDK2 (0.58) CDK2METAP2APPCA2CA9
SCHEMBL18562228 0.88 CDK2 (0.47) CDK2METAP2APPCA1CA2
SCHEMBL10777776 0.86 CDK2 (0.55) CDK2METAP2APPMAPTLMNA
SCHEMBL10778237 0.85 TRIM24 (0.54) CDK2CA1CA2CA9ALDH1A1
SCHEMBL10777401 0.85 TRIM24 (0.54) CDK2CA1CA2CA9ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4689171-A LIQUID CRYSTALS BAYER AKTIENGESELLSCHAFT (DE) 1987-08-25 US disclosed