Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.55 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | DVL1 | O14640 | 2/20 | 0.44 |
| ▸ | DVL3 | Q92997 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10779581 | 0.95 | DRD4 (0.54) | DRD4CXCR3PDGFRBFGFR1PDGFRA | |
| Hydrochloric Acid SCHEMBL10784337 | 0.93 | DRD4 (0.52) | DRD4CXCR3PDGFRBFGFR1PDGFRA | |
| SCHEMBL10780527 | 0.91 | DRD4 (0.52) | DRD4CXCR3PDGFRBFGFR1PDGFRA | |
| Isopropyl Alcohol SCHEMBL11011590 | 0.91 | DRD4 (0.50) | DRD4CXCR3PDGFRBFGFR1PDGFRA | |
| SCHEMBL10782129 | 0.88 | DRD4 (0.54) | DRD4CXCR3SIGMAR1KCNH2 | |
| SCHEMBL10783772 | 0.87 | DRD4 (0.61) | DRD4CXCR3SIGMAR1ADRA2AADRA2B | |
| SCHEMBL10780851 | 0.86 | DRD4 (0.50) | DRD4CXCR3PDGFRBFGFR1PDGFRA | |
| SCHEMBL10779342 | 0.86 | DRD4 (0.50) | DRD4CXCR3SIGMAR1GAAKMT2A | |
| SCHEMBL10784433 | 0.86 | DRD4 (0.55) | DRD4CXCR3SIGMAR1 | |
| SCHEMBL10780039 | 0.86 | DRD4 (0.53) | DRD4CXCR3SIGMAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150505-B1 | 3-INDOLECARBOXAMIDE COMPOUNDS | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1987-04-01 | — | — | EP | disclosed |
| US-4581355-A | HYPOTENSIVE AGENTS, LIPOXYGENASE INHIBITORS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1986-04-08 | — | — | US | disclosed |
| EP-0150505-A2 | 3-Indolecarboxamide compounds | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1985-08-07 | — | — | EP | disclosed |