Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ESRRA | P11474 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PMM2 | O15305 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27987662 | 0.83 | TP53 (0.50) | TP53ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL10783819 | 0.80 | TP53 (0.47) | TP53ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL31316663 | 0.77 | TP53 (0.59) | TP53ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL22580254 | 0.76 | TP53 (0.58) | TP53ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL7815519 | 0.74 | TP53 (0.52) | TP53ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL303757 | 0.74 | CCR1 (0.55) | TP53ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL27988017 | 0.72 | GRM5 (0.56) | TP53ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL3879537 | 0.71 | KMT2A (0.62) | TP53ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL5868847 | 0.71 | TP53 (0.67) | TP53ALDH1A1HPGDCYP1A2CYP2D6 | |
| SCHEMBL6167291 | 0.70 | TP53 (0.62) | TP53ALDH1A1HPGDCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4665073-A | HISTAMINE H2-ANTAGONISTS | ICI AMERICAS INC. (GB) | 1987-05-12 | — | — | US | disclosed |
| EP-0060094-B1 | GUANIDINE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-01-22 | — | — | EP | disclosed |
| EP-0061318-B1 | GUANIDINOHETEROCYCLIC DERIVATIVES AS HISTAMINE H-2 ANTAGONISTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-10-09 | — | — | EP | disclosed |
| US-4451463-A | HISTAMINE ANTAGONIST, INHIBITOR OF GASTRIC ACID SECRETION | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-05-29 | — | — | US | disclosed |
| US-4447441-A | ANTIHISTAMINE, ANTIULCER AND ANTISECRETORY AGENT | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-05-08 | — | — | US | disclosed |
| EP-0103390-A2 | Guanidine-containing esters as histamine H2 receptor blockers | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-03-21 | — | — | EP | disclosed |
| EP-0061318-A2 | Guanidinoheterocyclic derivatives as histamine H-2 antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-09-29 | — | — | EP | disclosed |
| EP-0060094-A2 | Guanidine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-09-15 | — | — | EP | disclosed |