Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10789133 | 0.92 | SMN1; SMN2 (0.70) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| 1,2,4-Triazole SCHEMBL11500182 | 0.89 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL13246375 | 0.84 | SMN1; SMN2 (0.77) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL5655457 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL16358260 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| 1,2,4-Triazole SCHEMBL11381691 | 0.82 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL8995469 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL8995473 | 0.81 | ALDH1A1 (0.68) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL11129404 | 0.80 | PTGS1 (0.62) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL10932701 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4663462-A | CHEMICAL INTERMEDIATES FOR HYPOTENSIVES AND ADRENERGIC BLOCK AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1987-05-05 | — | — | US | claimed |
| US-4663462-A | CHEMICAL INTERMEDIATES FOR HYPOTENSIVES AND ADRENERGIC BLOCK AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1987-05-05 | — | — | US | disclosed |
| US-4577030-A | Azolyl-substituted phenoxy-aminopropanol derivatives | HOFFMANN-LA ROCHE INC. (US) | 1986-03-18 | — | — | US | disclosed |
| US-4387100-A | AROMATIC N-HETEROCYCLES, ADRENERGIC BLOCKING AGENTS, HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1983-06-07 | — | — | US | disclosed |