Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.33 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.33 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL9766208 | 0.98 | NAPRT (0.41) | NAPRTTSHRTDP1ALDH1A1CYP2C9 | |
| Pyridine SCHEMBL11518913 | 0.90 | NAPRT (0.47) | NAPRTTSHRTDP1ALDH1A1CYP2C9 | |
| Pyridine SCHEMBL2273114 | 0.90 | TDP1 (0.53) | NAPRTTSHRTDP1ALDH1A1L3MBTL1 | |
| Pyridine SCHEMBL7422031 | 0.89 | ALDH1A1 (0.46) | NAPRTTSHRTDP1ALDH1A1CYP2C9 | |
| Pyridine SCHEMBL11013969 | 0.87 | TDP1 (0.50) | NAPRTTSHRTDP1ALDH1A1L3MBTL1 | |
| Pyridine SCHEMBL907254 | 0.87 | ALDH1A1 (0.44) | NAPRTTSHRTDP1ALDH1A1CYP2C9 | |
| Pyridine SCHEMBL2993097 | 0.86 | ALDH1A1 (0.42) | NAPRTTSHRTDP1ALDH1A1CYP2C9 | |
| Pyridine SCHEMBL29276730 | 0.85 | TSHR (0.47) | NAPRTTSHRTDP1ALDH1A1 | |
| Ethyl Acetate SCHEMBL11520158 | 0.85 | ALDH1A1 (0.48) | TSHRALDH1A1CYP2C9CYP2C19CYP1A2 | |
| Pyridine SCHEMBL10977701 | 0.84 | NAPRT (0.60) | NAPRTTSHRTDP1ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863019-B2 | Propagating interleukin-15 specific monoclonal antibody for use as tool in controllig immune response | IMMUNEX CORPORATION (US) | 2011-01-04 | — | — | US | disclosed |
| US-20090018316-A1 | Propagating interleukin-15 specific monoclonal antibody for use as tool in controllig immune response | ANDERSON DIRK M | 2009-01-15 | — | — | US | disclosed |
| US-20050032167-A1 | Interleukin-15 receptors | ANDERSON DIRK M (US) | 2005-02-10 | — | — | US | disclosed |
| US-6764836-B2 | GENETIC ENGINEERED CULTURE PRODUCT; BINDING TO ANTIBODIES | IMMUNEX CORPORATION | 2004-07-20 | — | — | US | disclosed |
| US-20030158386-A1 | Interleukin-15 receptors | ALLIED LIGHTING SYSTEMS, INC. | 2003-08-21 | — | — | US | disclosed |
| US-6548065-B1 | Hybrids; genetic engineering | IMMUNEX CORPORATION | 2003-04-15 | — | — | US | disclosed |
| EP-0759942-B1 | INTERLEUKIN-15 RECEPTORS | IMMUNEX CORP (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-0772624-B1 | INTERLEUKIN-15 | IMMUNEX CORP (US) | 2000-09-13 | — | — | EP | disclosed |
| EP-0759942-A4 | INTERLEUKIN-15 RECEPTORS | IMMUNEX CORP (US) | 1999-05-12 | — | — | EP | disclosed |
| EP-0772624-A4 | INTERLEUKIN-15 | IMMUNEX CORP (US) | 1997-07-02 | — | — | EP | disclosed |
| EP-0772624-A1 | INTERLEUKIN-15 | IMMUNEX CORPORATION (US) | 1997-05-14 | — | — | EP | disclosed |
| EP-0759942-A1 | INTERLEUKIN-15 RECEPTORS | IMMUNEX CORPORATION (US) | 1997-03-05 | — | — | EP | disclosed |
| US-5591630-A | Monoclonal antibodies that bind interleukin-15 receptors | IMMUNEX CORPORATION (US) | 1997-01-07 | — | — | US | disclosed |
| US-5552303-A | POLYPEPTIDE DNA SEQUENCES FOR HYBRIDS FOR CELLS | IMMUNEX CORPORATION (US) | 1996-09-03 | — | — | US | disclosed |
| WO-1995030695-A1 | INTERLEUKIN-15 RECEPTORS | IMMUNEX CORPORATION (US) | 1995-11-16 | — | — | WO | disclosed |
| WO-1995027722-A1 | INTERLEUKIN-15 | IMMUNEX CORPORATION (US) | 1995-10-19 | — | — | WO | disclosed |