Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | PDE1A | P54750 | 2/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.31 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.31 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.31 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | LYN | P07948 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6762668 | 0.67 | PDE10A (0.39) | PDE10AFLT3ROCK1CLK4 | |
| SCHEMBL26621288 | 0.66 | PDE10A (0.34) | PDE10A | |
| SCHEMBL1907671 | 0.66 | PDE10A (0.34) | PDE10A | |
| SCHEMBL1905594 | 0.61 | KDR (0.45) | PDE10AMAP4K4SYKMAP4K2PKN2 | |
| SCHEMBL11537174 | 0.61 | CDK8 (0.49) | ADORA3MAP4K4MAP4K2AURKBKDR | |
| SCHEMBL10830581 | 0.61 | PDE10A (0.38) | PDE4APDE4DPDE10A | |
| SCHEMBL13936549 | 0.60 | ADORA3 (0.41) | PDE4APDE4BPDE4CPDE4DPDE1A | |
| Hydrochloric Acid SCHEMBL11540203 | 0.60 | CDK8 (0.47) | ADORA3MAP4K4SYKMAP4K2AURKB | |
| SCHEMBL10830608 | 0.59 | ROCK1 (0.35) | PDE10AMAP4K4SYKMAP4K2PKN2 | |
| SCHEMBL25114873 | 0.58 | KDM4E (0.40) | MAP4K4SYKMAP4K2PKN2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4643999-A | 2-substituted imidazo[1,2-c]pyrimidines having anxiolytic properties | ROUSSEL-UCLAF, A FRENCH BODY CORPORATE (FR) | 1987-02-17 | — | — | US | disclosed |