Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 12/20 | 0.62 |
| ▸ | PLAU | P00749 | 5/20 | 0.62 |
| ▸ | F2 | P00734 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1563104 | 0.82 | KDM4E (0.66) | ELANEPLAUF2KDM4ENR4A2 | |
| SCHEMBL31302274 | 0.82 | KDM4E (0.66) | ELANEPLAUF2KDM4ENR4A2 | |
| SCHEMBL4476722 | 0.81 | ELANE (0.72) | ELANEPLAUF2 | |
| SCHEMBL8111559 | 0.81 | ELANE (0.62) | ELANEPLAUF2KDM4ENR4A2 | |
| SCHEMBL1078543 | 0.81 | ELANE (0.62) | ELANEPLAUF2KDM4ENR4A2 | |
| SCHEMBL3452457 | 0.80 | ELANE (0.70) | ELANEPLAUF2 | |
| SCHEMBL28171820 | 0.80 | ELANE (0.61) | ELANEKDM4EHIF1AMEN1KMT2A | |
| SCHEMBL4258294 | 0.80 | TSHR (0.52) | ELANEPLAUF2KDM4EHIF1A | |
| SCHEMBL2432444 | 0.79 | ELANE (0.74) | ELANEPLAUF2 | |
| SCHEMBL717998 | 0.78 | ELANE (0.63) | ELANEPLAUF2KDM4ENR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459563-A2 | 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF | Albany Molecular Research, Inc. (US) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011008572-A2 | 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF | ALBANY MOLECULAR RESEARCH, INC. (US) | 2011-01-20 | — | — | WO | disclosed |