Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ELANE | P08246 | 7/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28171820 | 0.85 | ELANE (0.61) | TSHRCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1079201 | 0.80 | ELANE (0.62) | HIF1AELANEF2PLAUMAPT | |
| SCHEMBL20674557 | 0.79 | TSHR (0.47) | TSHRCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL960949 | 0.79 | ELANE (0.62) | TSHRCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL30251861 | 0.78 | KDM4E (0.62) | TSHRCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL27758519 | 0.78 | ELANE (0.57) | TSHRCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL496589 | 0.78 | KDM4E (0.62) | TSHRCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1967917 | 0.78 | TSHR (0.46) | TSHRCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL27937196 | 0.78 | TSHR (0.46) | TSHRCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7421574 | 0.76 | SCN9A (0.58) | TSHRSCN9ARORCMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101239950-A | 1-(substituted benzoyl)-indazole-3-carboxylate or amides compounds thereof, synthesis and application thereof | UNIV PLA 2ND MILITARY MEDICAL (CN) | 2008-08-13 | — | — | CN | claimed |
| CN-104812898-B | The method for treating metabolic syndrome by adjusting the β of heat shock protein (HSP) 90 | 博格有限责任公司 | 2018-01-30 | — | — | CN | disclosed |
| CN-104640855-B | Complement is by way of conditioning agent and application thereof | 诺华股份有限公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-104045625-A | INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK | PFIZER | 2014-09-17 | — | — | CN | disclosed |
| CN-103889976-A | Indazole compounds, compositions and methods of use | HOFFMANN LA ROCHE | 2014-06-25 | — | — | CN | disclosed |
| CN-101239950-B | 1-(substituted benzoyl)-indazole-3-carboxylate or amides compounds thereof, synthesis and application thereof | UNIV PLA 2ND MILITARY MEDICAL | 2011-01-19 | — | — | CN | disclosed |
| US-20090181968-A1 | Novel 3-Bicyclocarbonylaminopyridine-2-Carboxamides or 3-Bicyclocarbonylaminopyrazine-2-Carboxamides | ASTRAZENECA AB (SE) | 2009-07-16 | — | — | US | disclosed |
| EP-1957478-A2 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| CN-101239950-A | 1-(substituted benzoyl)-indazole-3-carboxylate or amides compounds thereof, synthesis and application thereof | UNIV PLA 2ND MILITARY MEDICAL (CN) | 2008-08-13 | — | — | CN | disclosed |
| WO-2007061360-A2 | NOVEL 3-BICYCLOCARBONYLAMINOPYRIDINE-2-CARBOXAMIDES OR 3-BICYCLOCARBONYLAMINOPYRAZINE-2-CARBOXAMIDES | ASTRAZENECA AB (SE) | 2007-05-31 | — | — | WO | disclosed |
| EP-1776338-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006013048-A1 | INDOLE, INDAZOLE OR INDOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-02-09 | — | — | WO | disclosed |
| EP-0558923-B1 | Diazabicyclo derivatives as 5-HT3 antagonists | NISSHIN FLOUR MILLING CO (JP) | 2000-05-24 | — | — | EP | disclosed |
| US-5344831-A | Antiemetics for treatment of nausea from chemotherapy | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1994-09-06 | — | — | US | disclosed |
| US-5256656-A | Antiserotonine agent | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1993-10-26 | — | — | US | disclosed |
| EP-0558923-A1 | Diazabicyclo derivatives as 5-HT3 antagonists | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1993-09-08 | — | — | EP | disclosed |
| US-5187166-A | Also useful as antipsychotic agents | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1993-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181968-A1 | Novel 3-Bicyclocarbonylaminopyridine-2-Carboxamides or 3-Bicyclocarbonylaminopyrazine-2-Carboxamides | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CCNA2, CNR2 | TSHR 1608/4885CYP1A2 49/4885CYP3A4 465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.