SCHEMBL10795244

SCHEMBL10795244

O=C1c2nc(Br)[nH]c2N(Cc2ccc(Cl)cc2)C2=NCCN12

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.55
HTT P42858 3/20 0.41
CLPP Q16740 2/20 0.39
GAA P10253 1/20 0.38
GFER P55789 1/20 0.38
TP53 P04637 1/20 0.38
KMT2A Q03164 3/20 0.37
LMNA P02545 2/20 0.36
GPR132 Q9UNW8 1/20 0.35
PRKAG1 P54619 1/20 0.34
PRKAA1 Q13131 1/20 0.34
PRKAB1 Q9Y478 1/20 0.34
MEN1 O00255 2/20 0.34
CYP3A4 P08684 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
HIF1A Q16665 1/20 0.34
KCNH2 Q12809 1/20 0.33
GRM2 Q14416 1/20 0.33
POLB P06746 1/20 0.32
SOS1 Q07889 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10798396 0.87 TSHR (0.55) TSHRHTTCLPPGAAGFER
SCHEMBL10798493 0.86 TSHR (0.54) TSHRHTTCLPPGAAGFER
SCHEMBL10800871 0.84 TSHR (0.52) TSHRHTTCLPPGAAGFER
SCHEMBL10795586 0.80 TSHR (0.57) TSHRHTTCLPPGAAGFER
Hydrochloric Acid SCHEMBL11069993 0.79 TSHR (0.56) TSHRHTTCLPPGAAGFER
SCHEMBL11163356 0.77 TSHR (0.57) TSHRHTTCLPPGAAGFER
Water SCHEMBL10795500 0.76 TSHR (0.56) TSHRHTTCLPPGAAGFER
SCHEMBL10798400 0.76 TSHR (0.55) TSHRHTTCLPPGAAGFER
SCHEMBL10798498 0.75 TSHR (0.54) TSHRHTTCLPPGAAGFER
SCHEMBL10795549 0.75 TSHR (0.54) TSHRHTTCLPPGAAGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4366156-A Antiallergic methods using diazaheterocyclopurines MEAD JOHNSON & COMPANY (US) 1982-12-28 US claimed
US-4642345-A BRONCHODILATOR AGENTS MEAD JOHNSON & COMPANY (US) 1987-02-10 US disclosed
US-4489078-A Diazaheterocyclopurines used as anti-broncho spasmatics and vasodilators MEAD JOHNSON & COMPANY (US) 1984-12-18 US disclosed
US-4404380-A BRONCHODILATORS, MEDIATOR RELEASE INHIBITORS, PHOSPHODIESTERASE INHIBITORS, AND VASODILATORS MEAD JOHNSON & COMPANY (US) 1983-09-13 US disclosed
US-4366156-A Antiallergic methods using diazaheterocyclopurines MEAD JOHNSON & COMPANY (US) 1982-12-28 US disclosed
US-4298734-A PHOSPHODIESTERASE INHIBITORS, BRONCHODILATORS, PERIPHERAL VASODILATORS MEAD JOHNSON & COMPANY (US) 1981-11-03 US disclosed