Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CLPP | Q16740 | 2/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10795290 | 0.86 | TSHR (0.50) | TSHRHTTTP53GAAGFER | |
| SCHEMBL10795586 | 0.86 | TSHR (0.57) | TSHRHTTTP53GAAGFER | |
| Hydrochloric Acid SCHEMBL11069993 | 0.85 | TSHR (0.56) | TSHRHTTTP53GAAGFER | |
| SCHEMBL10800156 | 0.80 | TSHR (0.52) | TSHRHTTTP53GAAKMT2A | |
| SCHEMBL11064805 | 0.77 | TSHR (0.47) | TSHRTP53GAAGFERACP1 | |
| SCHEMBL14540610 | 0.77 | TSHR (0.43) | TSHRHTTACP1KMT2ACLPP | |
| SCHEMBL11066311 | 0.76 | HTT (0.51) | TSHRHTTTP53GAAGFER | |
| SCHEMBL10795826 | 0.75 | GAA (0.52) | TSHRHTTTP53GAAGFER | |
| SCHEMBL11067241 | 0.70 | TSHR (0.42) | TSHRTP53GAAKMT2AMEN1 | |
| SCHEMBL11071194 | 0.70 | TSHR (0.43) | TSHRTP53GAAGFERACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4642345-A | BRONCHODILATOR AGENTS | MEAD JOHNSON & COMPANY (US) | 1987-02-10 | — | — | US | disclosed |
| US-4489078-A | Diazaheterocyclopurines used as anti-broncho spasmatics and vasodilators | MEAD JOHNSON & COMPANY (US) | 1984-12-18 | — | — | US | disclosed |
| US-4404380-A | BRONCHODILATORS, MEDIATOR RELEASE INHIBITORS, PHOSPHODIESTERASE INHIBITORS, AND VASODILATORS | MEAD JOHNSON & COMPANY (US) | 1983-09-13 | — | — | US | disclosed |
| US-4366156-A | Antiallergic methods using diazaheterocyclopurines | MEAD JOHNSON & COMPANY (US) | 1982-12-28 | — | — | US | disclosed |