SCHEMBL10795863

SCHEMBL10795863

CC(=O)OCc1cccc(Br)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.61
HCAR2 Q8TDS4 1/20 0.60
MAOB P27338 7/20 0.59
MMP1 P03956 1/20 0.56
MMP2 P08253 1/20 0.56
MMP9 P14780 1/20 0.56
MMP12 P39900 1/20 0.56
MAOA P21397 2/20 0.55
IDO1 P14902 2/20 0.55
AGXT P21549 2/20 0.55
GLA P06280 1/20 0.54
PARP15 Q460N3 2/20 0.51
PARP14 Q460N5 1/20 0.51
PARP10 Q53GL7 1/20 0.51
CYP3A4 P08684 2/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2D6 P10635 1/20 0.51
CYP2C19 P33261 1/20 0.51
FFAR1 O14842 1/20 0.49
FFAR4 Q5NUL3 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butane SCHEMBL10795645 0.95 HCAR2 (0.56) ALDH1A1HCAR2MAOBMMP1MMP2
SCHEMBL6709375 0.87 ALDH1A1 (0.73) ALDH1A1HCAR2MAOBCYP3A4
SCHEMBL27486398 0.85 MAOB (0.52) ALDH1A1HCAR2MAOBMMP1MMP2
SCHEMBL20267543 0.85 IDO1 (0.58) HCAR2MAOBMMP1MMP2MMP9
SCHEMBL27698538 0.84 HCAR2 (0.49) ALDH1A1HCAR2MAOBMMP1MMP2
SCHEMBL20954673 0.83 GLA (0.59) HCAR2MAOBMMP1MMP2MMP9
SCHEMBL26038096 0.83 HCAR2 (0.55) HCAR2MAOBMMP1MMP2MMP9
SCHEMBL14852200 0.83 MAOB (0.49) ALDH1A1HCAR2MAOBMMP1MMP2
SCHEMBL14808170 0.83 MAOB (0.56) HCAR2MAOBMMP1MMP2MMP9
SCHEMBL11226742 0.82 ALDH1A1 (0.61) ALDH1A1HCAR2MAOBMMP1MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020009176-A1 AMIDE COMPOUND HAVING BET PROTEOLYSIS-INDUCING ACTION AND MEDICINAL APPLICATION THEREOF 田辺三菱製薬株式会社 2020-01-09 WO disclosed
EP-2758377-A1 CYCLOALKYLNITRILE PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS Merck Sharp & Dohme Corp. (US) 2014-07-30 EP disclosed
EP-2758051-A1 CYANOMETHYLPYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS Merck Sharp & Dohme Corp. (US) 2014-07-30 EP disclosed
EP-2758050-A1 ACYCLIC CYANOETHYLPYRAZOLES AS JANUS KINASE INHIBITORS Merck Sharp & Dohme Corp. (US) 2014-07-30 EP disclosed
CN-101553483-B 2-(piperidin-4-yl)-4-phenoxy-or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors HOFFMANN LA ROCHE 2013-04-17 CN disclosed
WO-2013040863-A1 CYCLOALKYLNITRILE PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2013-03-28 WO disclosed
WO-2013043962-A1 CYANOMETHYLPYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2013-03-28 WO disclosed
WO-2013043964-A1 ACYCLIC CYANOETHYLPYRAZOLES AS JANUS KINASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2013-03-28 WO disclosed
CN-102816081-A Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme ABBOTT LAB 2012-12-12 CN disclosed
CN-102666485-A Alkene oxindole derivatives and their uses to treat obesity, diabetes and hyperlipidemia HOFFMANN LA ROCHE 2012-09-12 CN disclosed
CN-101267811-A Novel multi-cyclic compounds and their use REVOTAR BIOPHARMACEUTICALS AG (DE) 2008-09-17 CN disclosed
CN-101142172-A Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 enzyme ABBOTT LAB (US) 2008-03-12 CN disclosed
CN-1984894-A Compounds and compositions as PPAR modulators IRM LLC (BM) 2007-06-20 CN disclosed
CN-1859903-A Use of EP2 selective receptor agonists in medical treatment PFIZER PROD INC (US) 2006-11-08 CN disclosed
CN-1835924-A Fused compounds that inhibit vanilloid receptor subtype 1(vr1) receptor ABBOTT LAB (US) 2006-09-20 CN disclosed
CN-1211367-C Prostaglandin agonists and their use to treat bone disorders PFIZER (US) 2005-07-20 CN disclosed
CN-1566096-A Prostaglandin agonists and their use to treat bonedisorders PFIZER (US) 2005-01-19 CN disclosed
CN-1275123-A Prostaglandin agonists and their use to treat bone disorders PFIZER (US) 2000-11-29 CN disclosed
CN-1241176-A Prevention of loss and restoration of bone mass by certain prostaglandin agonists PFIZER (US) 2000-01-12 CN disclosed
US-4709081-A ETHERIFICATION, HYDROLYSIS CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA R.T. (HU) 1987-11-24 US disclosed