Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MITF | O75030 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | RAD52 | P43351 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TOP2A | P11388 | 14/20 | 0.53 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814010 | 0.87 | TOP2A (0.45) | POLBNPC1MITFRAB9ADNMT1 | |
| SCHEMBL10801353 | 0.84 | TOP2A (0.72) | POLBNPC1MITFRAB9ADNMT1 | |
| SCHEMBL10801104 | 0.82 | TOP2A (0.54) | TOP2AMAPK13EIF2AK2MAPK12MAPK11 | |
| SCHEMBL10805231 | 0.82 | TOP2A (0.54) | POLBKMT2ASMN1; SMN2TOP2AMAPK13 | |
| SCHEMBL10806468 | 0.81 | TOP2A (0.49) | POLBNPC1MITFRAB9ADNMT1 | |
| SCHEMBL10801535 | 0.81 | TOP2A (0.42) | POLBNPC1MITFRAB9ADNMT1 | |
| SCHEMBL10806341 | 0.81 | POLB (0.48) | POLBNPC1MITFRAB9ADNMT1 | |
| SCHEMBL10994405 | 0.80 | POLB (0.48) | POLBNPC1MITFRAB9ADNMT1 | |
| SCHEMBL10801161 | 0.79 | KMT2A (0.47) | POLBNPC1MITFRAB9ADNMT1 | |
| SCHEMBL10800105 | 0.78 | NPC1 (0.38) | POLBNPC1MITFRAB9ADNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0103381-B1 | SUBSTITUTED ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONES | WARNER-LAMBERT COMPANY (US) | 1987-09-23 | — | — | EP | disclosed |
| US-4556654-A | ANTICARCINOGENIC, FUNGICIDES, ANTISEPTICS | WARNER-LAMBERT COMPANY (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0103381-A1 | Substituted anthra(1,9-cd)pyrazol-6(2H)-ones | WARNER-LAMBERT COMPANY (US) | 1984-03-21 | — | — | EP | disclosed |