Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 15/20 | 0.42 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10801094 | 0.89 | TOP2A (0.46) | TOP2A | |
| SCHEMBL10802391 | 0.85 | TOP2A (0.60) | TOP2A | |
| SCHEMBL10805350 | 0.85 | TOP2A (0.42) | TOP2A | |
| SCHEMBL10800308 | 0.84 | TOP2A (0.44) | TOP2APOLBNPC1HTTRAB9A | |
| SCHEMBL9127738 | 0.83 | TOP2A (0.50) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL10800421 | 0.83 | ATM (0.36) | TOP2ARAD52 | |
| SCHEMBL10802508 | 0.83 | TOP2A (0.41) | TOP2A | |
| SCHEMBL10800769 | 0.82 | TOP2A (0.38) | TOP2ASMN1; SMN2 | |
| SCHEMBL10799708 | 0.81 | POLB (0.55) | TOP2ATOP2BPOLBNPC1MITF | |
| SCHEMBL10800408 | 0.81 | TOP2A (0.46) | TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0103381-B1 | SUBSTITUTED ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONES | WARNER-LAMBERT COMPANY (US) | 1987-09-23 | — | — | EP | claimed |
| EP-0103381-A1 | Substituted anthra(1,9-cd)pyrazol-6(2H)-ones | WARNER-LAMBERT COMPANY (US) | 1984-03-21 | — | — | EP | claimed |
| EP-0103381-B1 | SUBSTITUTED ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONES | WARNER-LAMBERT COMPANY (US) | 1987-09-23 | — | — | EP | disclosed |
| US-4556654-A | ANTICARCINOGENIC, FUNGICIDES, ANTISEPTICS | WARNER-LAMBERT COMPANY (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0103381-A1 | Substituted anthra(1,9-cd)pyrazol-6(2H)-ones | WARNER-LAMBERT COMPANY (US) | 1984-03-21 | — | — | EP | disclosed |