Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10805095 | 0.92 | TOP2A (0.55) | TOP2AMEN1USP2LMNATP53 | |
| SCHEMBL10799694 | 0.92 | TOP2A (0.54) | TOP2AMEN1USP2LMNATP53 | |
| SCHEMBL10801787 | 0.88 | TOP2A (0.69) | TOP2AMEN1USP2LMNATP53 | |
| Teloxantrone SCHEMBL782387 | 0.87 | TOP2A (0.70) | TOP2AMEN1USP2LMNATP53 | |
| SCHEMBL10801133 | 0.87 | TOP2A (0.55) | TOP2AMEN1USP2LMNATP53 | |
| SCHEMBL10807458 | 0.86 | TOP2A (0.50) | TOP2AMEN1USP2LMNATP53 | |
| Teloxantrone SCHEMBL9177269 | 0.86 | TOP2A (0.69) | TOP2AMEN1USP2LMNATP53 | |
| Teloxantrone SCHEMBL29397399 | 0.85 | TOP2A (0.68) | TOP2AMEN1USP2LMNATP53 | |
| Teloxantrone SCHEMBL3195 | 0.85 | TOP2A (0.68) | TOP2AMEN1USP2LMNATP53 | |
| SCHEMBL10800389 | 0.85 | TOP2A (0.57) | TOP2AMEN1USP2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0103381-B1 | SUBSTITUTED ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONES | WARNER-LAMBERT COMPANY (US) | 1987-09-23 | — | — | EP | claimed |
| EP-0103381-A1 | Substituted anthra(1,9-cd)pyrazol-6(2H)-ones | WARNER-LAMBERT COMPANY (US) | 1984-03-21 | — | — | EP | claimed |
| EP-0103381-B1 | SUBSTITUTED ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONES | WARNER-LAMBERT COMPANY (US) | 1987-09-23 | — | — | EP | disclosed |
| US-4556654-A | ANTICARCINOGENIC, FUNGICIDES, ANTISEPTICS | WARNER-LAMBERT COMPANY (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0103381-A1 | Substituted anthra(1,9-cd)pyrazol-6(2H)-ones | WARNER-LAMBERT COMPANY (US) | 1984-03-21 | — | — | EP | disclosed |