Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10806123 | 0.78 | MAPT (0.42) | MAPTTDP1MEN1ALDH1A1KMT2A | |
| SCHEMBL1480589 | 0.70 | KDM4E (0.39) | MAPTTDP1ABCG2ALDH1A1KMT2A | |
| SCHEMBL11441072 | 0.70 | HPGD (0.41) | MAPTTDP1ABCG2ALDH1A1KMT2A | |
| SCHEMBL222062 | 0.69 | MAPT (0.55) | MAPTTDP1ABCG2PDE4DMEN1 | |
| SCHEMBL11376027 | 0.69 | KDM4E (0.43) | MAPTTDP1ABCG2PDE4DMEN1 | |
| SCHEMBL3674074 | 0.68 | CA9 (0.50) | MAPTTDP1ABCG2ALDH1A1KMT2A | |
| SCHEMBL30701949 | 0.68 | CA9 (0.50) | MAPTTDP1ABCG2ALDH1A1KMT2A | |
| SCHEMBL5288290 | 0.67 | AOC3 (0.40) | MAPTTDP1ABCG2ALDH1A1KMT2A | |
| SCHEMBL11520794 | 0.67 | TDP1 (0.47) | MAPTTDP1ABCG2PDE4DALDH1A1 | |
| SCHEMBL11371629 | 0.67 | KDM4E (0.39) | MAPTTDP1ABCG2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210828-A2 | Tetrahydroisoquinoline derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SMITHKLINE BEECHAM CORPORATION (US) | 1987-02-04 | — | — | EP | disclosed |