Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10802344 | 0.78 | MAPT (0.40) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9476144 | 0.75 | CNR2 (0.47) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL14750665 | 0.72 | PPARA (0.48) | MAPTGAAMEN1KMT2AKDM4E | |
| SCHEMBL16784850 | 0.70 | PPARA (0.46) | MAPTGAAMEN1KMT2AKDM4E | |
| SCHEMBL6613660 | 0.70 | KMT2A (0.59) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL27413433 | 0.70 | PIN1 (0.46) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL490607 | 0.70 | AOC3 (0.46) | MAPTGAAMEN1KMT2AKDM4E | |
| SCHEMBL14722446 | 0.69 | ALDH1A1 (0.59) | GAAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9475980 | 0.69 | ALDH1A1 (0.49) | MAPTGAAKMT2AKDM4EALDH1A1 | |
| SCHEMBL10806998 | 0.69 | NFE2L2 (0.41) | MAPTGAAMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210828-A2 | Tetrahydroisoquinoline derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SMITHKLINE BEECHAM CORPORATION (US) | 1987-02-04 | — | — | EP | disclosed |