Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.76 |
| ▸ | GBA1 | P04062 | 1/20 | 0.76 |
| ▸ | CNR1 | P21554 | 1/20 | 0.76 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.76 |
| ▸ | HRH2 | P25021 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10805556 | 1.00 | CYP2D6 (0.76) | CYP2D6KCNH2SLC6A4LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL10808670 | 0.98 | CYP3A4 (0.77) | CYP2D6KCNH2SLC6A4LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL10808667 | 0.98 | CYP3A4 (0.77) | CYP2D6KCNH2SLC6A4LMNACYP1A2 | |
| Ambroxol SCHEMBL7855003 | 0.87 | CYP2D6 (1.00) | CYP2D6KCNH2SLC6A4LMNACYP1A2 | |
| SCHEMBL22927153 | 0.87 | CYP2D6 (0.74) | CYP2D6KCNH2SLC6A4LMNACYP1A2 | |
| SCHEMBL23318121 | 0.87 | CYP2D6 (0.74) | CYP2D6KCNH2SLC6A4LMNACYP1A2 | |
| Ambroxol SCHEMBL423712 | 0.87 | CYP2D6 (1.00) | CYP2D6KCNH2SLC6A4LMNACYP1A2 | |
| SCHEMBL23300547 | 0.87 | CYP2D6 (0.74) | CYP2D6KCNH2SLC6A4LMNACYP1A2 | |
| SCHEMBL23300546 | 0.87 | CYP2D6 (0.74) | CYP2D6KCNH2SLC6A4LMNACYP1A2 | |
| Ambroxol SCHEMBL18702 | 0.87 | CYP2D6 (1.00) | CYP2D6KCNH2SLC6A4LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147475-B1 | AMINOCYCLOHEXANOL DERIVATIVES HAVING AN EXPECTORANT ACTIVITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MAGIS FARMACEUTICI S.p.A. (IT) | 1987-03-18 | — | — | EP | claimed |
| EP-0147475-A1 | Aminocyclohexanol derivatives having an expectorant activity, process for their preparation and pharmaceutical compositions containing them | MAGIS FARMACEUTICI S.p.A. (IT) | 1985-07-10 | — | — | EP | claimed |
| US-4528393-A | Derivatives having expectorant activity, the procedure for their preparation and the pharmaceutical compositions which contain them | MAGIS FARMACEUTICI S.R.L. (IT) | 1985-07-09 | — | — | US | claimed |
| EP-0147475-B1 | AMINOCYCLOHEXANOL DERIVATIVES HAVING AN EXPECTORANT ACTIVITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MAGIS FARMACEUTICI S.p.A. (IT) | 1987-03-18 | — | — | EP | disclosed |
| EP-0147475-A1 | Aminocyclohexanol derivatives having an expectorant activity, process for their preparation and pharmaceutical compositions containing them | MAGIS FARMACEUTICI S.p.A. (IT) | 1985-07-10 | — | — | EP | disclosed |
| US-4528393-A | Derivatives having expectorant activity, the procedure for their preparation and the pharmaceutical compositions which contain them | MAGIS FARMACEUTICI S.R.L. (IT) | 1985-07-09 | — | — | US | disclosed |