Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10808950 | 1.00 | PDE3B (0.42) | PDE3BPDE3AKDM4EHPGDPDE5A | |
| SCHEMBL10814200 | 0.81 | KDM4E (0.41) | KDM4EHPGDCYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL10811224 | 0.81 | KDM4E (0.41) | KDM4EHPGDCYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL11259649 | 0.79 | PDE3A (0.61) | PDE3BPDE3AKDM4EHPGDPDE5A | |
| SCHEMBL11259651 | 0.79 | PDE3A (0.61) | PDE3BPDE3AKDM4EHPGDPDE5A | |
| SCHEMBL9770554 | 0.78 | PDE3A (0.59) | PDE3BPDE3AKDM4EHPGDPDE5A | |
| SCHEMBL10814113 | 0.78 | KDM4E (0.39) | PDE3BPDE3AKDM4EHPGDLMNA | |
| SCHEMBL10814107 | 0.78 | KDM4E (0.39) | PDE3BPDE3AKDM4EHPGDLMNA | |
| SCHEMBL10927371 | 0.78 | HTT (0.39) | PDE3BPDE3AKDM4EHPGDPDE5A | |
| SCHEMBL7384727 | 0.75 | PDE3B (0.62) | PDE3BPDE3AKDM4EHPGDPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4650806-A | Cardiotonic 5-(heterylcarbonyl)-pyridones | STERLING DRUG INC. (US) | 1987-03-17 | — | — | US | disclosed |
| US-4567186-A | 5-Heteryl-1,6-naphthyridin-2(1H)-ones, cardiotonic use thereof and intermediates therefor | STERLING DRUG INC. (US) | 1986-01-28 | — | — | US | disclosed |