Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 9/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | PDE4A | P27815 | 2/20 | 0.59 |
| ▸ | BLM | P54132 | 2/20 | 0.59 |
| ▸ | PDE5A | O76074 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381624 | 0.86 | KDM4E (0.57) | PDE3APDE3BKDM4EHPGDPDE4A | |
| SCHEMBL11020885 | 0.85 | PDE3A (0.54) | PDE3APDE3BKDM4EHPGDPDE4A | |
| SCHEMBL10808228 | 0.85 | KDM4E (0.48) | PDE3APDE3BKDM4EHPGDPDE4A | |
| SCHEMBL7384727 | 0.83 | PDE3B (0.62) | PDE3APDE3BKDM4EHPGDPDE4A | |
| SCHEMBL10808401 | 0.83 | PDE3A (0.52) | PDE3APDE3BKDM4EHPGDPDE4A | |
| SCHEMBL10809707 | 0.81 | KDM4E (0.43) | PDE3APDE3BKDM4EHPGDPDE4A | |
| SCHEMBL10807248 | 0.79 | KDM4E (0.43) | PDE3APDE3BKDM4EHPGDPDE4A | |
| SCHEMBL10814357 | 0.79 | PDE3A (0.44) | PDE3APDE3BKDM4EHPGDPDE4A | |
| SCHEMBL11020993 | 0.79 | PDE3A (0.53) | PDE3APDE3BKDM4EHPGDPDE4A | |
| SCHEMBL10808944 | 0.78 | PDE3B (0.42) | PDE3APDE3BKDM4EHPGDPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992452-A | Certain 5-acyl-2-(1H)-pyridinones useful in treating cardiac failure | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-02-12 | — | — | US | claimed |
| US-4650806-A | Cardiotonic 5-(heterylcarbonyl)-pyridones | STERLING DRUG INC. (US) | 1987-03-17 | — | — | US | claimed |
| US-4650806-A | Cardiotonic 5-(heterylcarbonyl)-pyridones | STERLING DRUG INC. (US) | 1987-03-17 | — | — | US | disclosed |
| EP-0191298-A2 | 1,6 -Naphthyridin-2(1H) - ones useful as cardiotonics and preparation thereof | STERLING DRUG INC. (US) | 1986-08-20 | — | — | EP | disclosed |
| US-4567186-A | 5-Heteryl-1,6-naphthyridin-2(1H)-ones, cardiotonic use thereof and intermediates therefor | STERLING DRUG INC. (US) | 1986-01-28 | — | — | US | disclosed |