Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TOP2A | P11388 | 3/20 | 0.53 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ALB | P02768 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8438107 | 0.91 | ALDH1A1 (0.49) | KDM4EKCNH2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL9636141 | 0.88 | KDM4E (0.69) | KDM4EKCNH2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL10809530 | 0.88 | KDM4E (0.44) | KDM4EKCNH2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL7821381 | 0.87 | KDM4E (0.69) | KDM4EKCNH2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL10400672 | 0.87 | KCNH2 (0.56) | KDM4EKCNH2ALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL10400523 | 0.86 | KDM4E (0.67) | KDM4EKCNH2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL10736927 | 0.85 | TOP2A (0.60) | KDM4EKCNH2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL10785816 | 0.85 | TOP2A (0.62) | KDM4EKCNH2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL9668066 | 0.85 | TOP2A (0.62) | KDM4EKCNH2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL10400589 | 0.85 | KDM4E (0.51) | KDM4EKCNH2ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4556658-A | 7-Amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acids and antibacterial agents containing these compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1985-12-03 | — | — | US | claimed |
| EP-0126355-B1 | 7-AMINO-1-CYCLOPROPYL-6,8-DIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE-CARBOXYLIC ACID, PROCESSES FOR THEIR PREPARATION AND ANTIBACTERIAL AGENTS CONTAINING THEM | BAYER AG (DE) | 1987-09-09 | — | — | EP | disclosed |
| US-4556658-A | 7-Amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acids and antibacterial agents containing these compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1985-12-03 | — | — | US | disclosed |
| EP-0126355-A1 | 7-Amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid, processes for their preparation and antibacterial agents containing them | BAYER AG (DE) | 1984-11-28 | — | — | EP | disclosed |