Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.59 |
| ▸ | PDE4A | P27815 | 8/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10815947 | 0.92 | PDE4A (0.62) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11466643 | 0.90 | PDE4A (0.63) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11476753 | 0.90 | PDE4A (0.62) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11613302 | 0.89 | ADORA2B (0.58) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11458768 | 0.88 | PDE4A (0.63) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11477589 | 0.86 | ADORA2B (0.61) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11466640 | 0.86 | PDE4A (0.65) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11460824 | 0.85 | PDE4A (0.64) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11471017 | 0.84 | PDE4A (0.69) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11460447 | 0.84 | PDE4A (0.61) | ADORA2APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4713455-A | FOR OBSTRUCTIVE DISORDERS OF THE RESPIRATORY TRACT | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-12-15 | — | — | US | disclosed |
| US-4616020-A | TREATING OBSTRUCTIVE RESPIRATORY DISEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0075850-B1 | PHARMACEUTICAL PREPARATIONS CONTAINING VICINAL DIHYDROXYALKYL XANTHINES, PROCESS FOR THE PREPARATION OF THE XANTHINES AND THE APPROPRIATE INTERMEDIATES THEREFOR | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-12-18 | — | — | EP | disclosed |
| EP-0075850-A2 | Pharmaceutical preparations containing vicinal dihydroxyalkyl xanthines, process for the preparation of the xanthines and the appropriate intermediates therefor | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-04-06 | — | — | EP | disclosed |