Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 8/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 8/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | NSD2 | O96028 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | IDE | P14735 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 10/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10807646 | 0.85 | PDE3B (0.46) | PDE3BPDE3AABL1RIN1TSHR | |
| SCHEMBL10811057 | 0.84 | PDE3B (0.51) | PDE3BPDE3AABL1RIN1TSHR | |
| SCHEMBL10805565 | 0.79 | PDE3B (0.44) | PDE3BPDE3AABL1RIN1TSHR | |
| SCHEMBL7341880 | 0.78 | PDE3B (0.53) | PDE3BPDE3AABL1RIN1TDP1 | |
| SCHEMBL10805601 | 0.72 | PDE3B (0.47) | PDE3BPDE3ATDP1GAAPDE4A | |
| SCHEMBL8441474 | 0.71 | PDE3B (0.42) | PDE3BPDE3AGAAPDE4APDE4B | |
| SCHEMBL22766845 | 0.71 | PDE3B (0.46) | PDE3BPDE3AGAAPDE4APDE4B | |
| SCHEMBL10807637 | 0.71 | PDE3B (0.46) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10803886 | 0.68 | ABL1 (0.72) | PDE3BPDE3AABL1RIN1TSHR | |
| SCHEMBL10632760 | 0.67 | PDE3B (0.70) | PDE3BPDE3ATSHRPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0079049-B1 | NOVEL SUBSTITUTED ALKANOYLIMIDAZOL-2-ONE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | disclosed |
| US-4447619-A | CARDIOTONIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-05-08 | — | — | US | disclosed |
| EP-0079049-A2 | Novel substituted alkanoylimidazol-2-one derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-05-18 | — | — | EP | disclosed |
| US-4367236-A | CARDIOTONIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-01-04 | — | — | US | disclosed |