Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 12/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | IDE | P14735 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10811057 | 0.81 | PDE3B (0.51) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11186838 | 0.80 | JAK2 (0.47) | PDE3BPDE3AJAK2THRBLMNA | |
| SCHEMBL10632760 | 0.79 | PDE3B (0.70) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10968412 | 0.78 | JAK2 (0.45) | PDE3BPDE3AJAK2THRBLMNA | |
| SCHEMBL10811069 | 0.78 | PDE3B (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9786614 | 0.78 | PDE3B (0.49) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10805601 | 0.76 | PDE3B (0.47) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL256096 | 0.76 | MAPT (0.56) | PDE3BPDE3ALMNAABL1GAA | |
| SCHEMBL22783664 | 0.75 | JAK2 (0.61) | JAK2THRBLMNADHODHNSD2 | |
| SCHEMBL22766845 | 0.75 | PDE3B (0.46) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0169164-B1 | IMIDAZOLONECARBONYLARYLIMIDAZOLES; METHOD OF MANUFACTURE, METHOD OF USE AND COMPOSITIONS USEFUL THEREOF | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-01-31 | — | — | EP | disclosed |
| US-4709043-A | Process for the preparation of imidazolonecarbonylarylimidazoles | SCHERING A.G. (DE) | 1987-11-24 | — | — | US | disclosed |
| EP-0169164-A1 | Imidazolonecarbonylarylimidazoles; method of manufacture, method of use and compositions useful thereof | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-01-22 | — | — | EP | disclosed |
| US-4556665-A | Cardiotonic 1,3-dihydro-4-[[(imidazol-1-yl)aryl]carbonyl]imidazol-2-ones | SCHERING A.G. (DE) | 1985-12-03 | — | — | US | disclosed |