Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 1/20 | 0.66 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.66 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10811793 | 1.00 | CXCL8 (0.66) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL10812030 | 0.88 | CXCL8 (0.63) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL10812817 | 0.88 | HPGD (0.67) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL10812824 | 0.88 | HPGD (0.67) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL10812026 | 0.88 | CXCL8 (0.63) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL10815501 | 0.88 | HPGD (0.60) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL10815506 | 0.88 | HPGD (0.60) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL10817631 | 0.86 | CXCL8 (0.60) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL10813143 | 0.86 | CXCL8 (0.60) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL10813135 | 0.86 | CXCL8 (0.60) | CXCL8AKR1B1PTGS1PTGS2GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0115424-B1 | PYRROLE-2-ACETYLAMINO ACID DERIVATIVES | McNeilab, Inc. (US) | 1987-11-04 | — | — | EP | claimed |
| EP-0115424-A1 | Pyrrole-2-acetylamino acid derivatives | McNeilab, Inc. (US) | 1984-08-08 | — | — | EP | claimed |