Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL10812328 | 0.95 | KMT2A (0.43) | KMT2ACHRM2ADRA2AADORA3CHRM1 | |
| Acetic Acid SCHEMBL2451694 | 0.93 | KMT2A (0.42) | KMT2ACHRM2ADRA2AADORA3CHRM1 | |
| Propionic Acid SCHEMBL2454250 | 0.91 | KMT2A (0.41) | KMT2ACHRM2ADRA2AADORA3CHRM1 | |
| Acetic Acid SCHEMBL29214011 | 0.85 | KMT2A (0.37) | KMT2ACHRM2ADRA2AADORA3CHRM1 | |
| Trifluoroacetic Acid SCHEMBL6115378 | 0.85 | KMT2A (0.41) | KMT2ACHRM2ADRA2AADORA3CHRM1 | |
| L-Lactic Acid SCHEMBL1328758 | 0.85 | KMT2A (0.37) | KMT2ACHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL98339 | 0.84 | — | — | |
| SCHEMBL1725286 | 0.84 | ACHE (0.48) | KMT2ACHRM2ADRA2AADORA3CHRM1 | |
| Methoxyacetic Acid SCHEMBL17418389 | 0.82 | KMT2A (0.35) | KMT2ACHRM2ADRA2AADORA3CHRM1 | |
| Sulfuric Acid SCHEMBL2866735 | 0.81 | KMT2A (0.36) | KMT2ACHRM2ADRA2AADORA3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0090366-B1 | 1-AZABICYCLO(3.2.0)HEPT-2-ENE-2-CARBOXYLIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-11-25 | — | — | EP | disclosed |