Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 18/20 | 0.83 |
| ▸ | PDE3A | Q14432 | 18/20 | 0.83 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10813255 | 0.91 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL10810746 | 0.84 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL10726035 | 0.79 | PDE3B (0.53) | PDE3BPDE3AGPR84UTS2R | |
| SCHEMBL7378876 | 0.78 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL7373709 | 0.77 | PDE3B (0.57) | PDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL7383599 | 0.76 | PDE3B (0.97) | PDE3BPDE3A | |
| SCHEMBL7384124 | 0.76 | PDE3B (0.56) | PDE3BPDE3AGPR84 | |
| SCHEMBL7376102 | 0.75 | PDE3B (0.63) | PDE3BPDE3A | |
| SCHEMBL10818371 | 0.74 | PDE3B (0.65) | PDE3BPDE3A | |
| SCHEMBL7382831 | 0.73 | PDE3B (0.63) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0101952-B1 | 5-ALKYL-1,6-NAPHTHYRIDIN-2(1H)-ONES, INTERMEDIATES, THEIR PREPARATION AND THEIR CARDIOTONIC USE | STERLING DRUG INC. (US) | 1987-09-23 | — | — | EP | disclosed |
| US-4559347-A | 3-Substituted-5-alkyl-1,6-naphthyridin-2(1H)-ones, cardiotonic use and preparation thereof | STERLING DRUG INC. (US) | 1985-12-17 | — | — | US | disclosed |
| US-4517190-A | 5-Alkyl-1,6-naphthyridin-2(1H)-ones and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-05-14 | — | — | US | disclosed |
| EP-0101952-A1 | 5-Alkyl-1,6-naphthyridin-2(1H)-ones, intermediates, their preparation and their cardiotonic use | STERLING DRUG INC. (US) | 1984-03-07 | — | — | EP | disclosed |
| US-4415580-A | Certain 2-(1H)-pyridinones cardiotonic compositions containing same and method of using same | STERLING DRUG INC. (US) | 1983-11-15 | — | — | US | disclosed |