Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 18/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 18/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373709 | 0.93 | PDE3B (0.57) | PDE3BPDE3AKDM4E | |
| SCHEMBL7384124 | 0.92 | PDE3B (0.56) | PDE3BPDE3AKDM4E | |
| SCHEMBL7382831 | 0.91 | PDE3B (0.63) | PDE3BPDE3AKDM4EHSD17B10 | |
| SCHEMBL7381637 | 0.85 | PDE3B (0.62) | PDE3BPDE3AKDM4E | |
| SCHEMBL7382500 | 0.83 | PDE3B (0.63) | PDE3BPDE3AKDM4E | |
| SCHEMBL10813255 | 0.78 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL10810746 | 0.77 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL10813106 | 0.75 | PDE3B (0.83) | PDE3BPDE3A | |
| SCHEMBL7378876 | 0.74 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL7381346 | 0.74 | PDE3B (0.61) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0134535-B1 | 1,6-NAPHTHYRIDIN DERIVATIVES USEFUL AS CARDIOTONICS AND PREPARATION THEREOF | STERLING DRUG INC. (US) | 1988-10-26 | — | — | EP | disclosed |
| US-4604399-A | 5-methyl(or ethyl)-1,6-naphthyridin-2(1H)-one 6-oxides, their preparation and the cardiotonic use thereof | STERLING DRUG INC. (US) | 1986-08-05 | — | — | US | disclosed |
| US-4532247-A | Increases cardiac contractility | STERLING DRUG INC. (US) | 1985-07-30 | — | — | US | disclosed |
| EP-0134535-A1 | 1,6-Naphthyridin derivatives useful as cardiotonics and preparation thereof | STERLING DRUG INC. (US) | 1985-03-20 | — | — | EP | disclosed |