Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.47 |
| ▸ | GAA | P10253 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 3/20 | 0.47 |
| ▸ | GFER | P55789 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | PLEC | Q15149 | 1/20 | 0.47 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7058901 | 0.85 | ALDH1A1 (0.45) | KDM4EGAAALDH1A1MAPTHPGD | |
| SCHEMBL3131960 | 0.82 | GAA (0.61) | KDM4EGAAALDH1A1MAPTHPGD | |
| SCHEMBL30269683 | 0.82 | GAA (0.61) | KDM4EGAAALDH1A1MAPTHPGD | |
| SCHEMBL6477662 | 0.81 | POLB (0.53) | KDM4EGAAALDH1A1MAPTHPGD | |
| SCHEMBL6449728 | 0.81 | KDM4E (0.44) | KDM4EGAAALDH1A1MAPTHPGD | |
| SCHEMBL7510413 | 0.81 | KDM4E (0.50) | KDM4EGAAALDH1A1MAPTHPGD | |
| SCHEMBL3842724 | 0.81 | KDM4E (0.50) | KDM4EGAAALDH1A1MAPTHPGD | |
| SCHEMBL11045821 | 0.80 | TTR (0.42) | KDM4EGAAALDH1A1MAPTHPGD | |
| SCHEMBL15515059 | 0.79 | KDM4E (0.49) | KDM4EGAAALDH1A1MAPTHPGD | |
| SCHEMBL18422047 | 0.79 | KDM4E (0.49) | KDM4EGAAALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110060043-A1 | INHIBITORS OF CELL PROLIFERATION AND USES THEREOF | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2011-03-10 | — | — | US | disclosed |
| EP-2268613-A2 | INHIBITORS OF CELL PROLIFERATION AND USES THEREOF | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009106361-A2 | INHIBITORS OF CELL PROLIFERATION AND USES THEREOF | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110060043-A1 | INHIBITORS OF CELL PROLIFERATION AND USES THEREOF | MKI67, CDKN1A, CCNI | KDM4E 1696/4885GAA 982/4885ALDH1A1 2365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.