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Medorinone

Medorinone

SCHEMBL10816601

CC(=O)c1ccc(=O)[nH]c1C=CN(C)C.Cc1nccc2[nH]c(=O)ccc12

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ PDE3B Q13370 17/20 0.56
▸ PDE3A Q14432 17/20 0.56
▸ KMT2A Q03164 1/20 0.36
▸ KDM4E B2RXH2 2/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ TSHR P16473 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7381643 0.82 MAPT (0.36) PDE3BPDE3AKMT2AKDM4EALDH1A1
SCHEMBL7381640 0.82 MAPT (0.36) PDE3BPDE3AKMT2AKDM4EALDH1A1
Medorinone SCHEMBL121782 0.75 PDE3B (1.00) PDE3BPDE3AKMT2AKDM4EALDH1A1
SCHEMBL10811980 0.69 HTT (0.35) KMT2AALDH1A1TSHR
SCHEMBL10813620 0.69 HTT (0.35) KMT2AALDH1A1TSHR
SCHEMBL7377447 0.68 HSP90AB1 (0.35) KMT2AALDH1A1
SCHEMBL10815504 0.68 PDE3B (0.31) PDE3BPDE3AGAA
SCHEMBL7377448 0.68 HSP90AB1 (0.35) KMT2AALDH1A1
SCHEMBL10815507 0.68 PDE3B (0.31) PDE3BPDE3AGAA
SCHEMBL10377563 0.68 ALDH1A1 (0.40) KMT2AKDM4EALDH1A1SMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0101952-B1 5-ALKYL-1,6-NAPHTHYRIDIN-2(1H)-ONES, INTERMEDIATES, THEIR PREPARATION AND THEIR CARDIOTONIC USE STERLING DRUG INC. (US) 1987-09-23 — — EP claimed
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