Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | USP2 | O75604 | 3/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.60 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11010744 | 1.00 | LMNA (0.61) | LMNAHTR2BPTGS1KDM4EUSP2 | |
| SCHEMBL11013328 | 0.93 | LMNA (0.64) | LMNAHTR2BPTGS1KDM4EUSP2 | |
| SCHEMBL11221145 | 0.90 | PTGS1 (0.64) | LMNAHTR2BPTGS1KDM4EUSP2 | |
| SCHEMBL11038084 | 0.89 | PTGS1 (0.66) | LMNAHTR2BPTGS1KDM4EUSP2 | |
| SCHEMBL11224348 | 0.89 | PTGS1 (0.66) | LMNAHTR2BPTGS1KDM4EUSP2 | |
| SCHEMBL10375581 | 0.88 | PTGS1 (0.67) | LMNAHTR2BPTGS1KDM4EUSP2 | |
| SCHEMBL9132440 | 0.87 | PTGS1 (0.65) | LMNAHTR2BPTGS1KDM4EUSP2 | |
| SCHEMBL10813296 | 0.86 | LMNA (0.73) | LMNAHTR2BPTGS1KDM4EUSP2 | |
| SCHEMBL10539753 | 0.86 | LMNA (0.63) | LMNAHTR2BPTGS1KDM4EUSP2 | |
| SCHEMBL10813283 | 0.85 | LMNA (0.75) | LMNAHTR2BPTGS1KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147177-B1 | ETHER PRODRUGS OF ANTI-INFLAMMATORY OXICAMS | PFIZER INC. (US) | 1987-10-14 | — | — | EP | disclosed |
| US-4551452-A | Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor | PFIZER INC. (US) | 1985-11-05 | — | — | US | disclosed |
| EP-0147177-A2 | Ether prodrugs of anti-inflammatory oxicams | PFIZER INC. (US) | 1985-07-03 | — | — | EP | disclosed |