SCHEMBL10821978

SCHEMBL10821978

CCCCOC(=O)c1ccc(Cl)c(C)c1CCCC

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.54
TDP1 Q9NUW8 2/20 0.54
L3MBTL1 Q9Y468 2/20 0.54
MAPK1 P28482 3/20 0.49
CYP3A4 P08684 3/20 0.49
TP53 P04637 1/20 0.49
ALDH1A1 P00352 6/20 0.48
ESR1 P03372 3/20 0.48
HSD17B10 Q99714 2/20 0.48
LMNA P02545 3/20 0.48
KMT2A Q03164 3/20 0.45
CYP1A2 P05177 3/20 0.44
CYP2C19 P33261 3/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
CYP2D6 P10635 1/20 0.44
NR1H2 P55055 1/20 0.44
RNASEL Q05823 1/20 0.44
CYP2C9 P11712 2/20 0.43
PDE4D Q08499 1/20 0.43
KDM4E B2RXH2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11300674 0.90 TSHR (0.55) TSHRTDP1L3MBTL1MAPK1CYP3A4
SCHEMBL10821840 0.86 TSHR (0.56) TSHRTDP1L3MBTL1MAPK1CYP3A4
SCHEMBL27667027 0.79 TSHR (0.57) TSHRTDP1L3MBTL1MAPK1CYP3A4
SCHEMBL28717879 0.78 ALDH1A1 (0.60) TSHRTDP1L3MBTL1MAPK1CYP3A4
SCHEMBL6229742 0.78 ESR1 (0.59) TSHRTDP1L3MBTL1MAPK1CYP3A4
SCHEMBL10604217 0.77 ALDH1A1 (0.56) TSHRTDP1L3MBTL1MAPK1CYP3A4
SCHEMBL29127351 0.77 TSHR (0.54) TSHRTDP1L3MBTL1MAPK1CYP3A4
SCHEMBL28718635 0.76 ALDH1A1 (0.54) TSHRTDP1L3MBTL1MAPK1CYP3A4
SCHEMBL10822068 0.76 ALDH1A1 (0.51) TSHRTDP1L3MBTL1MAPK1CYP3A4
SCHEMBL11062678 0.75 TSHR (0.64) TSHRTDP1L3MBTL1MAPK1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0182872-A4 A PROCESS FOR THE PREPARATION OF CYCLOBUTENE-SUBSTITUTED AROMATIC HYDROCARBONS. DOW CHEMICAL CO (US) 1986-08-21 EP disclosed
EP-0182872-A1 A PROCESS FOR THE PREPARATION OF CYCLOBUTENE-SUBSTITUTED AROMATIC HYDROCARBONS. DOW CHEMICAL CO (US) 1986-06-04 EP disclosed
WO-1985005355-A1 A PROCESS FOR THE PREPARATION OF CYCLOBUTENE-SUBSTITUTED AROMATIC HYDROCARBONS THE DOW CHEMICAL COMPANY (US) 1985-12-05 WO disclosed