Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.50 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2973782 | 0.85 | CALM1 (0.61) | CALM1BCL2BCL2L1MAOBTSHR | |
| SCHEMBL2045801 | 0.80 | CALM1 (0.55) | CALM1LTA4HLMNAIDH1 | |
| SCHEMBL1829354 | 0.80 | CALM1 (0.55) | CALM1BCL2BCL2L1ALDH1A1LTA4H | |
| SCHEMBL1829180 | 0.78 | CALM1 (0.52) | CALM1LTA4HIDH1 | |
| SCHEMBL2051544 | 0.78 | CALM1 (0.52) | CALM1LTA4HIDH1 | |
| SCHEMBL6586984 | 0.78 | CALM1 (0.52) | CALM1LTA4HIDH1 | |
| SCHEMBL19462983 | 0.76 | CALM1 (0.44) | CALM1BCL2BCL2L1MAOATSHR | |
| SCHEMBL6604926 | 0.74 | HTR2C (0.50) | CALM1TSHRLMNACYP1A2ADRA2A | |
| SCHEMBL2585502 | 0.74 | CALM1 (0.42) | CALM1BCL2BCL2L1MAOAMAOB | |
| Diphenylmethane SCHEMBL1303 | 0.69 | CALM1 (1.00) | CALM1BCL2BCL2L1MAOBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0185079-A1 | — | CIBA GEIGY AG | 1986-06-25 | — | — | EP | disclosed |
| WO-1986000066-A1 | N-SUBSTITUTED BUTYRAMIDE DERIVATIVES | CIBA-GEIGY AG (CH) | 1986-01-03 | — | — | WO | disclosed |