CALM1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL224550	0.47	6/20
SCHEMBL65276	0.46	4/20
SCHEMBL43447	0.44	4/20
SCHEMBL108087	0.70	3/20
SCHEMBL58054	0.58	3/20
SCHEMBL58055	0.58	3/20
SCHEMBL427550	0.52	3/20
SCHEMBL356412	0.51	3/20
Ammonia Solution, Strong (SCHEMBL303558)	0.51	3/20
SCHEMBL175622	0.49	3/20
SCHEMBL436880	0.49	3/20
SCHEMBL64288	0.48	3/20
SCHEMBL88823	0.45	3/20
SCHEMBL402666	0.44	3/20
SCHEMBL410079	0.42	3/20
SCHEMBL63547	0.41	3/20
Hydrochloric Acid (SCHEMBL444357)	0.41	3/20
7-Hydroxyflavone (SCHEMBL312148)	1.00	2/20
SCHEMBL311405	0.82	2/20
SCHEMBL108050	0.72	2/20

Clinical trials — most relevant to CALM1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
COMS for Chronic Ulcers Treatment	PHASE4	RECRUITING
Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease	PHASE2	COMPLETED
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy	PHASE2	RECRUITING
The Response To Ajmaline Provocation in Healthy Subjects	PHASE2	UNKNOWN
S 48168 (ARM 210) for the Treatment of RYR1-related Myopathies (RYR1-RM)	PHASE1	COMPLETED
Breakpoint Analysis of de Novo Apparently Balanced Chromosomal Translocations	EARLY_PHASE1	COMPLETED
Glutamine Supplementation in People With Immune Dysregulation	EARLY_PHASE1	WITHDRAWN
Prevalence of Constitutional Mismatch-repair Deficiency Among Suspected Neurofibromatosis Type 1/Legius Syndrome Children Without a Malignancy and Without a NF1 or SPRED1 Mutation	nan	UNKNOWN
The Prevalence of RYR1-related Disease	nan	NOT_YET_RECRUITING
A Natural History Study of RYR1-Related Disorders	nan	RECRUITING
Relationship of Gestational Age and Urine Concentration of S100B in Preterm and Term Infants in the First Week of Life	nan	COMPLETED
Calmodulin Gene Mutations in Patients With Ventricular Arrhythmia of Unknown Origin - A Screening Study	nan	WITHDRAWN
Influence of Pulse Electromagnetic Field Therapy on Myocardial Ischemia	nan	RECRUITING
ADH1 and ADH2 Disease Monitoring Study (DMS)	nan	ACTIVE_NOT_RECRUITING
Multispectral Optoacoustic Tomography for Advanced Imaging of Centronuclear Myopathy	nan	RECRUITING
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY)	nan	COMPLETED
Radicle Calm RDH: A Study Assessing the Impact of Health and Wellness Products on Feelings of Anxiety and Related Health Outcomes	nan	COMPLETED
Comparison of Two Methods to Diagnose Coronary Artery Disease	nan	COMPLETED
A Study That Collects Participant Data and Biospecimens to Analyze Pathogenic Exosomes That Mediate Increased Vascular Dementia Risk in Individuals With Herpes Zoster.	nan	RECRUITING
Delineating the Molecular Spectrum and the Clinical, Imaging and Neuronal Phenotype of Chopra-Amiel-Gordon Syndrome	nan	RECRUITING
Characterization of Patients With Cardiomyopathy to Identify Critical Patients Candidates for Cardiac Transplantation	nan	RECRUITING
Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders	nan	UNKNOWN
Transcranial Magnetic Stimulation (TMS) Studies of Dystonia	nan	COMPLETED
Early Detection of Cardiomyopathy by Speckle Echo, High Sensitive Troponin and Cardiac Ryanodine Receptors	nan	UNKNOWN
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
Joint Determinants of Bone Density and CVD Calcification	nan	COMPLETED
Multicenter Study of Patients With SHANK3 Mutations: Identification of Genes Modificators in Phelan-McDermid Syndrome (EUQ13)	nan	NOT_YET_RECRUITING
Evaluation of A Clinical Diagnostic Test for CRDS	nan	RECRUITING
Clinical and Genetic Study of Autism Spectrum Disorder	nan	COMPLETED
Determining the Association of Chromosomal Variants With Non-PV Triggers and Ablation-outcome in AF (DECAF)	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CALM1 binder may also engage these)

Protein	Name	Similarity
P0DP33	—	1.000	P0DP33 →
Q6YNX6	—	1.000	Q6YNX6 →
P0DP28	—	1.000	P0DP28 →
P0DP25	—	1.000	P0DP25 →
P0DP26	—	1.000	P0DP26 →
P0DP24	—	1.000	P0DP24 →
P0DP29	—	1.000	P0DP29 →
P0DP27	—	1.000	P0DP27 →
P62144	—	1.000	P62144 →
P62156	—	1.000	P62156 →
Q7T3T2	—	1.000	Q7T3T2 →
P02594	—	1.000	P02594 →
Q9U6D3	—	1.000	Q9U6D3 →
P62151	—	1.000	P62151 →
Q5RAD2	—	1.000	Q5RAD2 →
Q6R520	—	1.000	Q6R520 →
P0DP34	—	1.000	P0DP34 →
P62157	—	1.000	P62157 →
Q71UH6	—	1.000	Q71UH6 →
P0DP30	—	1.000	P0DP30 →
P0DP31	—	1.000	P0DP31 →
Q6IT78	—	1.000	Q6IT78 →
P0DP35	—	1.000	P0DP35 →
Q9UB37	—	1.000	Q9UB37 →
P21251	—	1.000	P21251 →
P07463	—	1.000	P07463 →
P62149	—	1.000	P62149 →
Q6PI52	—	1.000	Q6PI52 →
Q95NR9	—	1.000	Q95NR9 →
P62160	—	1.000	P62160 →