Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HCK | P08631 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4301715 | 0.81 | GCK (0.53) | HCKBTKGCK | |
| SCHEMBL956574 | 0.71 | GCK (0.48) | NOTUMLMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1106972 | 0.69 | SMN1; SMN2 (0.58) | NOTUMELOVL1LMNASMN1; SMN2KDM4E | |
| SCHEMBL20064373 | 0.69 | ALDH1A1 (0.51) | TP53NOTUMLMNASMN1; SMN2KDM4E | |
| SCHEMBL16703930 | 0.68 | SMN1; SMN2 (0.54) | NOTUMELOVL1LMNASMN1; SMN2KDM4E | |
| SCHEMBL16699478 | 0.68 | SMN1; SMN2 (0.54) | NOTUMELOVL1LMNASMN1; SMN2KDM4E | |
| SCHEMBL15885992 | 0.67 | KMT2A (0.48) | HCKBTKLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL2656936 | 0.67 | NPC1 (0.50) | HCKBTKGCKNPC1RAB9A | |
| SCHEMBL943092 | 0.67 | NPC1 (0.50) | HCKBTKLMNASMN1; SMN2KDM4E | |
| SCHEMBL944372 | 0.66 | GCK (0.51) | GCKNPC1RAB9AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268633-A1 | PYRIDAZINONE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009127544-A1 | PYRIDAZINONE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-22 | — | — | WO | disclosed |