Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 14/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.41 |
| ▸ | CTSD | P07339 | 6/20 | 0.39 |
| ▸ | REN | P00797 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10825161 | 1.00 | BACE1 (0.41) | BACE1BACE2CTSDREN | |
| SCHEMBL10825121 | 1.00 | BACE1 (0.41) | BACE1BACE2CTSDREN | |
| SCHEMBL10825178 | 0.87 | REN (0.49) | BACE1REN | |
| SCHEMBL10825155 | 0.87 | REN (0.49) | BACE1REN | |
| SCHEMBL10825159 | 0.87 | REN (0.49) | BACE1REN | |
| SCHEMBL8437180 | 0.83 | MME (0.37) | BACE1 | |
| SCHEMBL8437182 | 0.83 | MME (0.37) | BACE1 | |
| SCHEMBL30567410 | 0.83 | BACE1 (0.38) | BACE1CTSD | |
| SCHEMBL30254038 | 0.83 | BACE1 (0.38) | BACE1CTSD | |
| Water SCHEMBL29655489 | 0.82 | MME (0.36) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4629724-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1986-12-16 | — | — | US | claimed |
| US-4629724-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1986-12-16 | — | — | US | disclosed |