Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 8/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | MYLK | Q15746 | 3/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL952625 | 0.79 | MAP3K5 (0.43) | MAP3K5MYLKTNF | |
| SCHEMBL944325 | 0.74 | MAP3K5 (0.66) | MAP3K5TP53 | |
| SCHEMBL978873 | 0.72 | MAP3K5 (0.41) | MAP3K5MYLKTNF | |
| SCHEMBL6127726 | 0.70 | MAP3K5 (0.48) | MAP3K5MYLKTNF | |
| SCHEMBL979098 | 0.70 | MAP3K5 (0.42) | MAP3K5MYLKTNFTGFBR1 | |
| SCHEMBL945052 | 0.69 | TP53 (0.44) | TP53 | |
| SCHEMBL2217733 | 0.67 | TP53 (0.47) | TP53 | |
| SCHEMBL993196 | 0.66 | MAP3K5 (0.56) | MAP3K5MYLK | |
| SCHEMBL15153024 | 0.66 | MAP3K5 (0.35) | MAP3K5MYLKTNF | |
| SCHEMBL977782 | 0.65 | MAP3K5 (0.41) | MAP3K5TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | disclosed |