Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 7/20 | 0.56 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.45 |
| ▸ | CBLB | Q13191 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | MYLK | Q15746 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20544694 | 0.86 | MAP3K5 (0.56) | MAP3K5CBLBLMNAGAACLK1 | |
| SCHEMBL952626 | 0.84 | MAP3K5 (0.67) | MAP3K5CBLBLMNAGAASMN1; SMN2 | |
| SCHEMBL945572 | 0.82 | MAP3K5 (0.68) | MAP3K5CBLBLMNAGAACLK1 | |
| SCHEMBL14482053 | 0.81 | MAP3K5 (0.55) | MAP3K5CBLBLMNAGAACLK1 | |
| SCHEMBL17180502 | 0.81 | MAP3K5 (0.57) | MAP3K5CBLBLMNAGAACLK1 | |
| SCHEMBL20473168 | 0.81 | MAP3K5 (0.57) | MAP3K5CBLBLMNAGAACLK1 | |
| SCHEMBL16354006 | 0.80 | MAP3K5 (0.49) | MAP3K5CBLBLMNAGAACLK1 | |
| SCHEMBL943988 | 0.79 | MAP3K5 (0.69) | MAP3K5CBLBLMNAGAACLK1 | |
| SCHEMBL945360 | 0.79 | MAP3K5 (0.66) | MAP3K5CBLBLMNAGAACLK1 | |
| SCHEMBL14482051 | 0.79 | MAP3K5 (0.63) | MAP3K5CBLBLMNAGAACLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | disclosed |