Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 4/20 | 0.61 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.59 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.59 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 5/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2264510 | 0.78 | PDK2 (0.62) | PDK2PDK4PDK1PDK3CNR1 | |
| SCHEMBL2269040 | 0.77 | PDK2 (0.61) | PDK2PDK4PDK1PDK3PGR | |
| SCHEMBL3138211 | 0.77 | PDK2 (0.61) | PDK2PDK4PDK1PDK3CNR1 | |
| SCHEMBL31117008 | 0.77 | PDK2 (0.61) | PDK2PDK4PDK1PDK3CNR1 | |
| SCHEMBL31032206 | 0.77 | PDK2 (0.56) | PDK2PDK4PDK1PDK3CNR1 | |
| SCHEMBL10470225 | 0.76 | PDK2 (0.59) | PDK2PDK4PDK1PDK3CNR1 | |
| SCHEMBL10828347 | 0.74 | PDK2 (0.57) | PDK2PDK4PDK1PDK3KMT2A | |
| SCHEMBL10915783 | 0.73 | PGR (0.41) | PDK2KMT2AMEN1PGR | |
| SCHEMBL10482937 | 0.72 | MEN1 (0.36) | PDK2PDK4CNR1HTTGPR35 | |
| SCHEMBL3150359 | 0.71 | PDK2 (0.52) | PDK2PDK4PDK1PDK3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4622336-A | ANALGESICS | SANDOZ LTD. (CH) | 1986-11-11 | — | — | US | disclosed |
| WO-1983002610-A1 | DERIVATIVES OF 3,3-DIALKYL-INDOLIN AND OF 3,3-ALKYLENE-INDOLIN, METHOD FOR PRODUCING THEM AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | SANDOZ AG (CH) | 1983-08-04 | — | — | WO | disclosed |