Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | DHFR | P00374 | 3/20 | 0.42 |
| ▸ | PPID | Q08752 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10828794 | 1.00 | L3MBTL1 (0.56) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL27519961 | 0.88 | L3MBTL1 (0.53) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL6448822 | 0.88 | L3MBTL1 (0.53) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL9556474 | 0.88 | L3MBTL1 (0.53) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL9556468 | 0.88 | L3MBTL1 (0.53) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL6448813 | 0.88 | L3MBTL1 (0.53) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL8320541 | 0.85 | L3MBTL1 (0.59) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL9601970 | 0.85 | L3MBTL1 (0.59) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL1143549 | 0.85 | L3MBTL1 (0.59) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL10828876 | 0.82 | MAPT (0.54) | L3MBTL1KMT2APOLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4564616-A | Anti-cancer quinazoline derivatives | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1986-01-14 | — | — | US | disclosed |
| EP-0031237-B1 | QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTI-CANCER AGENTS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1984-10-17 | — | — | EP | disclosed |
| US-4447608-A | ANTITUMOR AGENTS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1984-05-08 | — | — | US | disclosed |
| EP-0031237-A1 | Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1981-07-01 | — | — | EP | disclosed |